Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells

The γ-retroviral vector is a gene delivery vehicle that is commonly used in gene therapy. Despite its efficacy, its strong enhancers contributed to malignant transformations in some hematopoietic stem cell (HSC) gene therapy trials. A safer version without viral enhancers (SIN) is available, but its...

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Detalles Bibliográficos
Autores principales: Ghani, Karim, Boivin-Welch, Michael, Roy, Sylvie, Dakiw-Piaceski, Angela, Barbier, Martin, Pope, Elena, Germain, Lucie, Caruso, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610700/
https://www.ncbi.nlm.nih.gov/pubmed/31312667
http://dx.doi.org/10.1016/j.omtm.2019.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610700/
https://www.ncbi.nlm.nih.gov/pubmed/31312667
http://dx.doi.org/10.1016/j.omtm.2019.05.013

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