Cargando…

Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24(−/−)) exhibit premature age-related musculoskeletal pathologies similar to those observed in children with Hutchinson-Gilford progeria syndrome (HGPS)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawakami, Yohei, Hambright, William S., Takayama, Koji, Mu, Xiaodong, Lu, Aiping, Cummins, James H., Matsumoto, Tomoyuki, Yurube, Takashi, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610712/ https://www.ncbi.nlm.nih.gov/pubmed/31312666 http://dx.doi.org/10.1016/j.omtm.2019.05.011

Ejemplares similares

mTOR signaling plays a critical role in the defects observed in muscle‐derived stem/progenitor cells isolated from a murine model of accelerated aging
por: Takayama, Koji, et al.
Publicado: (2016)

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
por: Takayama, Koji, et al.
Publicado: (2014)

Rapamycin for aging stem cells
por: Hambright, William S., et al.
Publicado: (2020)

Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration
por: Song, Minjung, et al.
Publicado: (2013)

Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells
por: Liu, Lei, et al.
Publicado: (2022)

Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty
por: Tsujimoto, Ryu, et al.
Publicado: (2015)

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
por: Lavasani, Mitra, et al.
Publicado: (2012)

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide
por: Akinci, Baris, et al.
Publicado: (2017)

Progeroide Syndrome: Alterung, Hautalterung und Mechanismen progeroider Erkrankungen
por: Koschitzki, Kevin, et al.
Publicado: (2023)

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
por: Birkisdóttir, María B., et al.
Publicado: (2021)

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice
por: Proto, Jonathan D., et al.
Publicado: (2017)

Broad segmental progeroid changes in short-lived Ercc1(−/Δ7) mice
por: Dollé, Martijn E.T., et al.
Publicado: (2011)

Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model
por: Yurube, Takashi, et al.
Publicado: (2014)

Myotonic Dystrophy—A Progeroid Disease?
por: Meinke, Peter, et al.
Publicado: (2018)

Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes
por: Kato, Hisaya, et al.
Publicado: (2022)

Dedifferentiation rescues senescence of progeria cells but only while pluripotent
por: Niedernhofer, Laura J, et al.
Publicado: (2011)

Fontaine progeroid syndrome—A case report
por: Lally, Sinéad, et al.
Publicado: (2022)

Insights into aging from progeroid syndrome epigenetics
por: Bejaoui, Yosra, et al.
Publicado: (2023)

Rescue of ankylosing hip following open reduction and internal fixation of acetabular fracture by surgical resection of heterotopic ossification: A case report
por: Kitayama, Kazumichi, et al.
Publicado: (2018)

Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors
por: Cheng, Haizi, et al.
Publicado: (2022)

Cellular expansion of MSCs: Shifting the regenerative potential
por: Miclau, Katherine, et al.
Publicado: (2022)

Partial Ablation of Non-Myogenic Progenitor Cells as a Therapeutic Approach to Duchenne Muscular Dystrophy
por: Gao, Zhanguo, et al.
Publicado: (2021)

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
por: Mu, Xiaodong, et al.
Publicado: (2020)

Multiple huge subchondral cysts associated with pseudogout in the bilateral knees: a case report and review of the literatures
por: Minoda, Masaya, et al.
Publicado: (2011)

Inaccurate rotational component position in image-free navigated unicompartmental knee arthroplasty
por: Toda, Akihiko, et al.
Publicado: (2016)

Early postoperative clinical recovery of robotic arm-assisted vs. image-based navigated Total hip Arthroplasty
por: Shibanuma, Nao, et al.
Publicado: (2021)

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
por: Koshimizu, Eriko, et al.
Publicado: (2011)

Spartan deficiency causes genomic instability and progeroid phenotypes
por: Maskey, Reeja S., et al.
Publicado: (2014)

Genomic instability and DNA replication defects in progeroid syndromes
por: Burla, Romina, et al.
Publicado: (2018)

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome
por: Crochemore, Clément, et al.
Publicado: (2023)

Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells
por: Mu, Xiaodong, et al.
Publicado: (2013)

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24(−/−) Progeria Mouse Model
por: Hambright, William S., et al.
Publicado: (2023)

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle
por: Liu, Lei, et al.
Publicado: (2022)

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
por: Carrero, Dido, et al.
Publicado: (2016)

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome
por: Pignolo, Robert J., et al.
Publicado: (2020)

Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence
por: O’hara, Kelsey, et al.
Publicado: (2022)

Biallelic variants in YRDC cause a developmental disorder with progeroid features
por: Schmidt, Julia, et al.
Publicado: (2021)

Platelet-Rich Plasma Promotes the Proliferation of Human Muscle Derived Progenitor Cells and Maintains Their Stemness
por: Li, Hongshuai, et al.
Publicado: (2013)

Rapamycin Rescues the Poor Developmental Capacity of Aged Porcine Oocytes
por: Lee, Seung Eun, et al.
Publicado: (2014)

In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice
por: van Thiel, Bibi S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qml0qkjaiu4bkfv6qmvfmkgpif