Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

BACKGROUND: Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (DCM), due to an impaired catabolism of BCAA, and if stimul...

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Detalles Bibliográficos
Autores principales: Uddin, Golam M., Zhang, Liyan, Shah, Saumya, Fukushima, Arata, Wagg, Cory S., Gopal, Keshav, Al Batran, Rami, Pherwani, Simran, Ho, Kim L., Boisvenue, Jamie, Karwi, Qutuba G., Altamimi, Tariq, Wishart, David S., Dyck, Jason R. B., Ussher, John R., Oudit, Gavin Y., Lopaschuk, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610921/
https://www.ncbi.nlm.nih.gov/pubmed/31277657
http://dx.doi.org/10.1186/s12933-019-0892-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610921/
https://www.ncbi.nlm.nih.gov/pubmed/31277657
http://dx.doi.org/10.1186/s12933-019-0892-3

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