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C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum

BACKGROUND: Conditional ablation of the Smarca5 gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulated in the cerebellum of Smarca5 mutant mice. Complement pr...

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Detalles Bibliográficos
Autores principales: Young, Kevin G., Yan, Keqin, Picketts, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610970/
https://www.ncbi.nlm.nih.gov/pubmed/31272467
http://dx.doi.org/10.1186/s12974-019-1530-4