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Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism
BACKGROUND: Blood coagulation factor VIIa (FVIIa) plays its critical physiological role in the initiation of hemostasis. Even so, recombinant FVIIa is successfully used as a bypassing agent for factor VIII or IX in the treatment of bleeds in patients with severe hemophilia with inhibitors. To invest...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611371/ https://www.ncbi.nlm.nih.gov/pubmed/31294329 http://dx.doi.org/10.1002/rth2.12211 |