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Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism

BACKGROUND: Blood coagulation factor VIIa (FVIIa) plays its critical physiological role in the initiation of hemostasis. Even so, recombinant FVIIa is successfully used as a bypassing agent for factor VIII or IX in the treatment of bleeds in patients with severe hemophilia with inhibitors. To invest...

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Detalles Bibliográficos
Autores principales:	Jiang, Longguang, Xie, Xie, Li, Jinyu, Persson, Egon, Huang, Mingdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles: Haemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611371/ https://www.ncbi.nlm.nih.gov/pubmed/31294329 http://dx.doi.org/10.1002/rth2.12211

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