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Modified Simon’s minimax and optimal two-stage designs for single-arm phase II cancer clinical trials
Simon’s two-stage design and the admissible two-stage design have been commonly used in practice for single-arm phase II clinical trials when the primary endpoint is binary. The ethical benefit of the two-stage design over the single-stage design is attained by the early termination of the trial whe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611508/ https://www.ncbi.nlm.nih.gov/pubmed/31303960 http://dx.doi.org/10.18632/oncotarget.26981 |