Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis remains unknown. Here we present cryo-EM structures of SNF2h-...

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Detalles Bibliográficos
Autores principales: Armache, Jean Paul, Gamarra, Nathan, Johnson, Stephanie L, Leonard, John D, Wu, Shenping, Narlikar, Geeta J, Cheng, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611695/
https://www.ncbi.nlm.nih.gov/pubmed/31210637
http://dx.doi.org/10.7554/eLife.46057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611695/
https://www.ncbi.nlm.nih.gov/pubmed/31210637
http://dx.doi.org/10.7554/eLife.46057

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