Cargando…

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis remains unknown. Here we present cryo-EM structures of SNF2h-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Armache, Jean Paul, Gamarra, Nathan, Johnson, Stephanie L, Leonard, John D, Wu, Shenping, Narlikar, Geeta J, Cheng, Yifan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611695/ https://www.ncbi.nlm.nih.gov/pubmed/31210637 http://dx.doi.org/10.7554/eLife.46057

Ejemplares similares

The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
por: Gamarra, Nathan, et al.
Publicado: (2018)

Ion counting demonstrates a high electrostatic field generated by the nucleosome
por: Gebala, Magdalena, et al.
Publicado: (2019)

An asymmetric centromeric nucleosome
por: Ichikawa, Yuichi, et al.
Publicado: (2018)

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
por: Sundaramoorthy, Ramasubramanian, et al.
Publicado: (2018)

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
por: Bacic, Luka, et al.
Publicado: (2021)

Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler
por: Levendosky, Robert F, et al.
Publicado: (2019)

DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes
por: Lyons, David B, et al.
Publicado: (2017)

A synthetic biology approach to probing nucleosome symmetry
por: Ichikawa, Yuichi, et al.
Publicado: (2017)

Effective dynamics of nucleosome configurations at the yeast PHO5 promoter
por: Wolff, Michael Roland, et al.
Publicado: (2021)

Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation
por: Henikoff, Steven, et al.
Publicado: (2020)

Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling
por: Brzezinka, Krzysztof, et al.
Publicado: (2016)

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
por: Worden, Evan J, et al.
Publicado: (2020)

The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1
por: Skene, Peter J, et al.
Publicado: (2014)

Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells
por: Pott, Sebastian
Publicado: (2017)

CTCF confers local nucleosome resiliency after DNA replication and during mitosis
por: Owens, Nick, et al.
Publicado: (2019)

The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
por: Morrison, Emma A, et al.
Publicado: (2018)

The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription
por: Hildreth, A Elizabeth, et al.
Publicado: (2020)

The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals
por: Chavez, Carolina, et al.
Publicado: (2019)

Promoter nucleosome dynamics regulated by signalling through the CTD code
por: Materne, Philippe, et al.
Publicado: (2015)

Nucleosomes impede Cas9 access to DNA in vivo and in vitro
por: Horlbeck, Max A, et al.
Publicado: (2016)

Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription
por: Zhou, Zhen, et al.
Publicado: (2017)

The dynamic nature of the human origin recognition complex revealed through five cryoEM structures
por: Jaremko, Matt J, et al.
Publicado: (2020)

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
por: Di Cerbo, Vincenzo, et al.
Publicado: (2014)

Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding
por: Willhoft, Oliver, et al.
Publicado: (2017)

Cryo-EM structure of the human Sirtuin 6-nucleosome complex
por: Chio, Un Seng, et al.
Publicado: (2023)

Cryo-EM structure of the human Sirtuin 6–nucleosome complex
por: Chio, Un Seng, et al.
Publicado: (2023)

Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly
por: Li, Xuan, et al.
Publicado: (2016)

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking
por: Chio, Un Seng, et al.
Publicado: (2023)

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation
por: Velazquez Camacho, Oscar, et al.
Publicado: (2017)

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2
por: Tafur, Lucas, et al.
Publicado: (2019)

Cryo-EM structure of SWI/SNF chromatin remodeling complex with nucleosome
por: Han, Yan, et al.
Publicado: (2020)

Massively multiplex single-molecule oligonucleosome footprinting
por: Abdulhay, Nour J, et al.
Publicado: (2020)

Dynamics of nucleosome remodelling by individual ACF complexes
por: Blosser, Timothy R., et al.
Publicado: (2009)

Cryo-EM of nucleosome core particle interactions in trans
por: Bilokapic, Silvija, et al.
Publicado: (2018)

Nucleosomes and their complexes in the cryoEM era: Trends and limitations
por: Armeev, Grigoriy A., et al.
Publicado: (2022)

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes
por: Touray, Abdoulie O, et al.
Publicado: (2023)

UV Damage in DNA Promotes Nucleosome Unwrapping
por: Duan, Ming-Rui, et al.
Publicado: (2010)

The ACF chromatin-remodeling complex is essential for Polycomb repression
por: Wiles, Elizabeth T, et al.
Publicado: (2022)

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities
por: Manning, Benjamin J., et al.
Publicado: (2017)

Advances in phase plate cryo-EM imaging of DNA and nucleosomes
por: Chua, Eugene Y. D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kljbhgv3io7a659a4p1o99kgab