Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

Lysocin E, a 37-membered natural depsipeptide, induces rapid bacteriolysis in methicillin-resistant Staphylococcus aureus via a unique menaquinone-dependent mechanism, presenting a promising therapeutic lead. Despite the great medical importance, exploring the potential utility of its derivatives as...

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Detalles Bibliográficos
Autores principales: Itoh, Hiroaki, Tokumoto, Kotaro, Kaji, Takuya, Paudel, Atmika, Panthee, Suresh, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Inoue, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611794/
https://www.ncbi.nlm.nih.gov/pubmed/31278250
http://dx.doi.org/10.1038/s41467-019-10754-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611794/
https://www.ncbi.nlm.nih.gov/pubmed/31278250
http://dx.doi.org/10.1038/s41467-019-10754-4

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