Biodistribution and radiation dosimetry of the novel hypoxia PET probe [(18)F]DiFA and comparison with [(18)F]FMISO

BACKGROUND: To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[(18)F]-fluoropropyl)-2-nitroimidazole ([(18)F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity and efficient radiosynthesis. Here, we evaluated the radiation dosage, b...

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Detalles Bibliográficos
Autores principales: Watanabe, Shiro, Shiga, Tohru, Hirata, Kenji, Magota, Keiichi, Okamoto, Shozo, Toyonaga, Takuya, Higashikawa, Kei, Yasui, Hironobu, Kobayashi, Jun, Nishijima, Ken-ichi, Iseki, Ken, Matsumoto, Hiroki, Kuge, Yuji, Tamaki, Nagara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611855/
https://www.ncbi.nlm.nih.gov/pubmed/31278504
http://dx.doi.org/10.1186/s13550-019-0525-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611855/
https://www.ncbi.nlm.nih.gov/pubmed/31278504
http://dx.doi.org/10.1186/s13550-019-0525-6

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