Cargando…

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of the lung is progressively replaced by fibrotic scars. Myofibroblasts are the effector cells that excessively deposit extracellular matrix proteins thus compromising lung structure and function. Emerging...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kheirollahi, Vahid, Wasnick, Roxana M., Biasin, Valentina, Vazquez-Armendariz, Ana Ivonne, Chu, Xuran, Moiseenko, Alena, Weiss, Astrid, Wilhelm, Jochen, Zhang, Jin-San, Kwapiszewska, Grazyna, Herold, Susanne, Schermuly, Ralph T., Mari, Bernard, Li, Xiaokun, Seeger, Werner, Günther, Andreas, Bellusci, Saverio, El Agha, Elie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611870/ https://www.ncbi.nlm.nih.gov/pubmed/31278260 http://dx.doi.org/10.1038/s41467-019-10839-0

Ejemplares similares

Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration
por: Moiseenko, Alena, et al.
Publicado: (2020)

GLI1+ cells are a source of repair-supportive mesenchymal cells (RSMCs) during airway epithelial regeneration
por: Chu, Xuran, et al.
Publicado: (2022)

Validation of a Novel Fgf10(Cre–ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally
por: Chu, Xuran, et al.
Publicado: (2021)

Protocol for the generation of murine bronchiolospheres
por: Vazquez-Armendariz, Ana Ivonne, et al.
Publicado: (2021)

Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion
por: Chu, Xuran, et al.
Publicado: (2021)

PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis
por: Biasin, Valentina, et al.
Publicado: (2020)

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis
por: MacKenzie, BreAnne, et al.
Publicado: (2015)

Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis
por: Kheirollahi, Vahid, et al.
Publicado: (2022)

Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis
por: Wasnick, Roxana Maria, et al.
Publicado: (2022)

3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening
por: Vazquez-Armendariz, Ana Ivonne, et al.
Publicado: (2022)

Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy
por: Ahmadvand, Negah, et al.
Publicado: (2021)

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair
por: Quantius, Jennifer, et al.
Publicado: (2016)

Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury
por: El Agha, Elie, et al.
Publicado: (2014)

Use of the Reversible Myogenic to Lipogenic Transdifferentiation Switch for the Design of Pre-clinical Drug Screening in Idiopathic Pulmonary Fibrosis
por: Lingampally, Arun, et al.
Publicado: (2020)

Alveologenesis: key cellular players and fibroblast growth factor 10 signaling
por: Chao, Cho-Ming, et al.
Publicado: (2016)

Resident cell lineages are preserved in pulmonary vascular remodeling
por: Crnkovic, Slaven, et al.
Publicado: (2018)

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors
por: Chu, Xuran, et al.
Publicado: (2019)

Multilineage murine stem cells generate complex organoids to model distal lung development and disease
por: Vazquez‐Armendariz, Ana Ivonne, et al.
Publicado: (2020)

Role of Fibroblast Growth Factor 10 in Mesenchymal Cell Differentiation During Lung Development and Disease
por: Wu, Jin, et al.
Publicado: (2018)

Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner
por: Gungl, Anna, et al.
Publicado: (2018)

A Breath of Fresh Air on the Mesenchyme: Impact of Impaired Mesenchymal Development on the Pathogenesis of Bronchopulmonary Dysplasia
por: Chao, Cho-Ming, et al.
Publicado: (2015)

From Clones to Buds and Branches: The Use of Lung Organoids to Model Branching Morphogenesis Ex Vivo
por: Vazquez-Armendariz, Ana Ivonne, et al.
Publicado: (2021)

Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice
por: Hadzic, Stefan, et al.
Publicado: (2023)

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate
por: Li, Aimin, et al.
Publicado: (2016)

Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid- and Early Pseudoglandular Stages of Mouse Lung Development
por: Jones, Matthew R., et al.
Publicado: (2020)

Pharmacological Application of Growth Factors: Basic and Clinical
por: Xiao, Jian, et al.
Publicado: (2015)

Editorial: Liver Myofibroblasts
por: Kanta, Jiri, et al.
Publicado: (2016)

Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes
por: Deplewski, Dianne, et al.
Publicado: (2011)

Lipogenic gene expression profile in patients with gastric cancer
por: MIYACHI, KAZUHITO, et al.
Publicado: (2013)

Insulin-Related Lipohypertrophy: Lipogenic Action or Tissue Trauma?
por: Barola, Anjana, et al.
Publicado: (2018)

Lipogenic effects of androgen signaling in normal and malignant prostate
por: Mah, Chui Yan, et al.
Publicado: (2020)

Measurement of lipogenic flux by deuterium resolved mass spectrometry
por: Fu, Xiaorong, et al.
Publicado: (2021)

CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis
por: Birnhuber, Anna, et al.
Publicado: (2020)

Generation and Validation of miR-142 Knock Out Mice
por: Shrestha, Amit, et al.
Publicado: (2015)

Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis
por: Ahmadvand, Negah, et al.
Publicado: (2022)

Lipogenic metabolism: a viable target for prostate cancer treatment?
por: Liang, Mengmeng, et al.
Publicado: (2014)

Heterologous Expression of Xylanase Enzymes in Lipogenic Yeast Yarrowia lipolytica
por: Wang, Wei, et al.
Publicado: (2014)

Hepatic CREBZF as a novel transcriptional regulator of the lipogenic pathway
por: Liu, Junli
Publicado: (2019)

Hyperglobus and Pseudoptosis in Type 1 Lipogenic Thyroid Eye Disease
por: Azad, Amee D., et al.
Publicado: (2023)

Identification of proteins in laser-microdissected small cell numbers by SELDI-TOF and Tandem MS
por: Kwapiszewska, Grazyna, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_7n73gkbc6qvlghmq03ld5qnoq7