Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia

Activating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant Kras(G12D) in the mouse gastric mucosa has been shown to induce hyperplasia and metaplasia. However, the mechanisms by which Kras activation leads to...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Wen-Cheng, Zhou, Yunyun, Atfi, Azeddine, Xu, Keli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611983/
https://www.ncbi.nlm.nih.gov/pubmed/31276933
http://dx.doi.org/10.1016/j.neo.2019.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611983/
https://www.ncbi.nlm.nih.gov/pubmed/31276933
http://dx.doi.org/10.1016/j.neo.2019.06.003

Ejemplares similares