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Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia
Activating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant Kras(G12D) in the mouse gastric mucosa has been shown to induce hyperplasia and metaplasia. However, the mechanisms by which Kras activation leads to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Neoplasia Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611983/ https://www.ncbi.nlm.nih.gov/pubmed/31276933 http://dx.doi.org/10.1016/j.neo.2019.06.003 |