CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

The gene encoding the transcription factor C/EBPα is mutated in 10-15% of acute myeloid leukemia (AML) patients. N-terminal CEBPA mutations cause ablation of full-length C/EBPα without affecting the expression of a shorter oncogenic isoform, termed p30. The mechanistic basis of p30-induced leukemoge...

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Detalles Bibliográficos
Autores principales: Schmidt, Luisa, Heyes, Elizabeth, Scheiblecker, Lisa, Eder, Thomas, Volpe, Giacomo, Frampton, Jon, Nerlov, Claus, Valent, Peter, Grembecka, Jolanta, Grebien, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612510/
https://www.ncbi.nlm.nih.gov/pubmed/30679799
http://dx.doi.org/10.1038/s41375-019-0382-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612510/
https://www.ncbi.nlm.nih.gov/pubmed/30679799
http://dx.doi.org/10.1038/s41375-019-0382-3

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