Molecular footprint of Medawar’s mutation accumulation process in mammalian aging

Medawar's mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly deleterious germline mutations expressed in old age can drift to fixation and thereby lead to aging‐related phenotypes. Although widely cited, empirical evidence for this hyp...

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Detalles Bibliográficos
Autores principales: Turan, Zeliha Gözde, Parvizi, Poorya, Dönertaş, Handan Melike, Tung, Jenny, Khaitovich, Philipp, Somel, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612638/
https://www.ncbi.nlm.nih.gov/pubmed/31062469
http://dx.doi.org/10.1111/acel.12965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612638/
https://www.ncbi.nlm.nih.gov/pubmed/31062469
http://dx.doi.org/10.1111/acel.12965

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