Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice

Cav1.2 is the pore‐forming subunit of L‐type voltage‐gated calcium channel (LTCC) that plays an important role in calcium overload and cell death in Alzheimer's disease. LTCC activity can be regulated by estrogen, a sex steroid hormone that is neuroprotective. Here, we investigated the potentia...

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Detalles Bibliográficos
Autores principales: Lai, Yu‐Jie, Zhu, Bing‐Lin, Sun, Fei, Luo, Dong, Ma, Yuan‐Lin, Luo, Bio, Tang, Jing, Xiong, Ming‐Jian, Liu, Lu, Long, Yan, Hu, Xiao‐Tong, He, Ling, Deng, Xiao‐Juan, Zhang, John H., Yang, Jian, Yan, Zhen, Chen, Guo‐Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612642/
https://www.ncbi.nlm.nih.gov/pubmed/31012223
http://dx.doi.org/10.1111/acel.12961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612642/
https://www.ncbi.nlm.nih.gov/pubmed/31012223
http://dx.doi.org/10.1111/acel.12961

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