Cargando…

Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice

Cav1.2 is the pore‐forming subunit of L‐type voltage‐gated calcium channel (LTCC) that plays an important role in calcium overload and cell death in Alzheimer's disease. LTCC activity can be regulated by estrogen, a sex steroid hormone that is neuroprotective. Here, we investigated the potentia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Yu‐Jie, Zhu, Bing‐Lin, Sun, Fei, Luo, Dong, Ma, Yuan‐Lin, Luo, Bio, Tang, Jing, Xiong, Ming‐Jian, Liu, Lu, Long, Yan, Hu, Xiao‐Tong, He, Ling, Deng, Xiao‐Juan, Zhang, John H., Yang, Jian, Yan, Zhen, Chen, Guo‐Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612642/ https://www.ncbi.nlm.nih.gov/pubmed/31012223 http://dx.doi.org/10.1111/acel.12961

Ejemplares similares

Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women
por: Papp, Rita, et al.
Publicado: (2017)

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice
por: Wen, Qi‐Xin, et al.
Publicado: (2022)

Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia
por: Schmitt, Andrea, et al.
Publicado: (2022)

Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice
por: Luo, Biao, et al.
Publicado: (2023)

Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice
por: Fan, Yong-Gang, et al.
Publicado: (2019)

Regulation of Cardiac Cav1.2 Channels by Calmodulin
por: Kameyama, Masaki, et al.
Publicado: (2023)

The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes
por: Chen, Zi, et al.
Publicado: (2018)

Prognostic Value of CAV1 and CAV2 in Head and Neck Squamous Cell Carcinoma
por: He, Jingyu, et al.
Publicado: (2023)

Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APP/PS1 Double Transgenic Mice via the PI3K/Akt Pathway
por: Lin, Shi-Yi, et al.
Publicado: (2020)

Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma
por: Li, Shujin, et al.
Publicado: (2022)

HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin
por: Poulsen, Esben G., et al.
Publicado: (2012)

Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice
por: Zhou, Chun-ni, et al.
Publicado: (2018)

Allicin disrupts cardiac Cav1.2 channels via trafficking
por: Han, Dan, et al.
Publicado: (2019)

Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice
por: Luo, Min, et al.
Publicado: (2021)

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation
por: Lee, Chih-Yuan, et al.
Publicado: (2017)

Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells
por: Lin, Wenfeng, et al.
Publicado: (2023)

CART treatment improves memory and synaptic structure in APP/PS1 mice
por: Jin, Jia-li, et al.
Publicado: (2015)

FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression
por: FeiFei, Wang, et al.
Publicado: (2019)

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
por: Zhang, Jian-Xiang, et al.
Publicado: (2019)

The Calmodulin-Binding, Short Linear Motif, NSCaTE Is Conserved in L-Type Channel Ancestors of Vertebrate Cav1.2 and Cav1.3 Channels
por: Taiakina, Valentina, et al.
Publicado: (2013)

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases
por: Li, Yun, et al.
Publicado: (2022)

Correction: The Calmodulin-Binding, Short Linear Motif, NSCaTE Is Conserved in L-Type Channel Ancestors of Vertebrate Cav1.2 and Cav1.3 Channels
por: Taiakina, Valentina, et al.
Publicado: (2014)

Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice
por: Zeng, Yue-Qin, et al.
Publicado: (2014)

Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer
por: Wang, Yi, et al.
Publicado: (2023)

Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
por: Yang, Xiao-bo, et al.
Publicado: (2022)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

Atomic Mechanisms of Timothy Syndrome-Associated Mutations in Calcium Channel Cav1.2
por: Korkosh, Vyacheslav S., et al.
Publicado: (2019)

Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
por: Chen, Huan, et al.
Publicado: (2020)

Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma
por: Rong, Shi Song, et al.
Publicado: (2016)

WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Negatively Regulates TLR4-Mediated TNF-α and IL-6 Production by Proteasomal Degradation of TNF Receptor Associated Factor 6 (TRAF6)
por: Lin, Xiao-Wen, et al.
Publicado: (2013)

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice
por: Chen, Lizhi, et al.
Publicado: (2019)

Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice
por: Luo, Gang, et al.
Publicado: (2016)

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation
por: Wei, Meng, et al.
Publicado: (2022)

Cav1/EREG/YAP Axis in the Treatment Resistance of Cav1-Expressing Head and Neck Squamous Cell Carcinoma
por: Burgy, Mickaël, et al.
Publicado: (2021)

Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation
por: Ma, Jing, et al.
Publicado: (2023)

The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder
por: Qayyum, T, et al.
Publicado: (2012)

Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation
por: Andranovits, Stanislav, et al.
Publicado: (2017)

Calmodulin and ATP support activity of the Cav1.2 channel through dynamic interactions with the channel
por: Minobe, Etsuko, et al.
Publicado: (2017)

MYOC Promotes the Differentiation of C2C12 Cells by Regulation of the TGF-β Signaling Pathways via CAV1
por: Zhang, Yuhan, et al.
Publicado: (2021)

TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1
por: Lin, Lulu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jo0gusqvbpuce1uv0t8m60d4fv