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Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging
Aging is associated with increasing prevalence and severity of infections caused by a decline in bone marrow (BM) lymphopoiesis and reduced B‐cell repertoire diversity. The current study proposes a strategy to enhance immune responsiveness in aged mice and humans, through rejuvenation of the B linea...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612643/ https://www.ncbi.nlm.nih.gov/pubmed/31056853 http://dx.doi.org/10.1111/acel.12959 |