Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging

Aging is associated with increasing prevalence and severity of infections caused by a decline in bone marrow (BM) lymphopoiesis and reduced B‐cell repertoire diversity. The current study proposes a strategy to enhance immune responsiveness in aged mice and humans, through rejuvenation of the B linea...

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Detalles Bibliográficos
Autores principales: Avivi, Irit, Zisman‐Rozen, Simona, Naor, Shulamit, Dai, Isabelle, Benhamou, David, Shahaf, Gitit, Tabibian‐Keissar, Hilla, Rosenthal, Noemie, Rakovsky, Aviya, Hanna, Ammuri, Shechter, Arik, Peled, Eli, Benyamini, Noam, Dmitrukha, Ekaterina, Barshack, Iris, Mehr, Ramit, Melamed, Doron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612643/
https://www.ncbi.nlm.nih.gov/pubmed/31056853
http://dx.doi.org/10.1111/acel.12959

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