Using the structure of genome data in the design of deep neural networks for predicting amyotrophic lateral sclerosis from genotype

MOTIVATION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by aberrations in the genome. While several disease-causing variants have been identified, a major part of heritability remains unexplained. ALS is believed to have a complex genetic basis where non-additive combin...

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Detalles Bibliográficos
Autores principales: Yin, Bojian, Balvert, Marleen, van der Spek, Rick A A, Dutilh, Bas E, Bohté, Sander, Veldink, Jan, Schönhuth, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Ismb/Eccb 2019 Conference Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612814/
https://www.ncbi.nlm.nih.gov/pubmed/31510706
http://dx.doi.org/10.1093/bioinformatics/btz369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612814/
https://www.ncbi.nlm.nih.gov/pubmed/31510706
http://dx.doi.org/10.1093/bioinformatics/btz369

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