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PRISM: methylation pattern-based, reference-free inference of subclonal makeup

MOTIVATION: Characterizing cancer subclones is crucial for the ultimate conquest of cancer. Thus, a number of bioinformatic tools have been developed to infer heterogeneous tumor populations based on genomic signatures such as mutations and copy number variations. Despite accumulating evidence for t...

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Detalles Bibliográficos
Autores principales: Lee, Dohoon, Lee, Sangseon, Kim, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612819/
https://www.ncbi.nlm.nih.gov/pubmed/31510697
http://dx.doi.org/10.1093/bioinformatics/btz327