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Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose–response experiments
MOTIVATION: The efficacy of a chemical compound is often tested through dose–response experiments from which efficacy metrics, such as the IC(50), can be derived. The Marquardt–Levenberg algorithm (non-linear regression) is commonly used to compute estimations for these metrics. The analysis are how...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612849/ https://www.ncbi.nlm.nih.gov/pubmed/31510684 http://dx.doi.org/10.1093/bioinformatics/btz335 |