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TADOSS: computational estimation of tandem domain swap stability

SUMMARY: Proteins with highly similar tandem domains have shown an increased propensity for misfolding and aggregation. Several molecular explanations have been put forward, such as swapping of adjacent domains, but there is a lack of computational tools to systematically analyze them. We present th...

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Detalles Bibliográficos
Autores principales: Lafita, Aleix, Tian, Pengfei, Best, Robert B, Bateman, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612889/
https://www.ncbi.nlm.nih.gov/pubmed/30500878
http://dx.doi.org/10.1093/bioinformatics/bty974