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TADOSS: computational estimation of tandem domain swap stability
SUMMARY: Proteins with highly similar tandem domains have shown an increased propensity for misfolding and aggregation. Several molecular explanations have been put forward, such as swapping of adjacent domains, but there is a lack of computational tools to systematically analyze them. We present th...
Autores principales: | Lafita, Aleix, Tian, Pengfei, Best, Robert B, Bateman, Alex |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612889/ https://www.ncbi.nlm.nih.gov/pubmed/30500878 http://dx.doi.org/10.1093/bioinformatics/bty974 |
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