Cargando…
Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
Purpose: There is an urgent need for the development of novel, effective, and less toxic drugs to treat leukemia. Antimicrobial peptides (AMPs) have received much more attention as alternative chemotherapeutic agents. This study aimed to examined the cytotoxicity of a novel AMP myristoly-CM4 against...
Autores principales: | Zhang, Huidan, Han, Dongju, Lv, Tongtong, Liu, Kehang, Yang, Yunqing, Xu, Xixi, Chen, Yuqing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612960/ https://www.ncbi.nlm.nih.gov/pubmed/31308628 http://dx.doi.org/10.2147/DDDT.S207224 |
Ejemplares similares
-
N-myristoylation of Antimicrobial Peptide CM4 Enhances Its Anticancer Activity by Interacting With Cell Membrane and Targeting Mitochondria in Breast Cancer Cells
por: Li, Caiyun, et al.
Publicado: (2018) -
Effect of Hydrophobicity on the Anticancer Activity
of Fatty-Acyl-Conjugated CM4 in Breast Cancer Cells
por: Yang, Yunqing, et al.
Publicado: (2020) -
2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors
por: Wanyan, Yangke, et al.
Publicado: (2020) -
Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis
por: Wang, Wenjing, et al.
Publicado: (2019) -
Kinetics of Internalization and Cytotoxicity of Transferrin‐Neocarzinostatin Conjugate in Human Leukemia Cell Line, K562
por: Kohgo, Yutaka, et al.
Publicado: (1990)