Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets. Whereas the wild-type protein pr...

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Detalles Bibliográficos
Autores principales: De Santis, Riccardo, Alfano, Vincenzo, de Turris, Valeria, Colantoni, Alessio, Santini, Laura, Garone, Maria Giovanna, Antonacci, Giuseppe, Peruzzi, Giovanna, Sudria-Lopez, Emma, Wyler, Emanuel, Anink, Jasper J., Aronica, Eleonora, Landthaler, Markus, Pasterkamp, R. Jeroen, Bozzoni, Irene, Rosa, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613039/
https://www.ncbi.nlm.nih.gov/pubmed/31242416
http://dx.doi.org/10.1016/j.celrep.2019.05.085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613039/
https://www.ncbi.nlm.nih.gov/pubmed/31242416
http://dx.doi.org/10.1016/j.celrep.2019.05.085

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