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An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication
DNA damage-induced signaling by ATR and CHK1 inhibits DNA replication, stabilizes stalled and collapsed replication forks, and mediates the repair of multiple classes of DNA lesions. We and others have shown that ATR kinase inhibitors, three of which are currently undergoing clinical trials, induce...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613105/ https://www.ncbi.nlm.nih.gov/pubmed/31209037 http://dx.doi.org/10.1073/pnas.1903418116 |