Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Cyclic AMP (cAMP) phosphodiesterase-4 (PDE4) enzymes degrade cAMP and underpin the compartmentalization of cAMP signaling through their targeting to particular protein complexes and intracellular locales. We describe the discovery and characterization of a small-molecule compound that allosterically...

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Detalles Bibliográficos
Autores principales: Omar, Faisa, Findlay, Jane E., Carfray, Gemma, Allcock, Robert W., Jiang, Zhong, Moore, Caitlin, Muir, Amy L., Lannoy, Morgane, Fertig, Bracy A., Mai, Deborah, Day, Jonathan P., Bolger, Graeme, Baillie, George S., Schwiebert, Erik, Klussmann, Enno, Pyne, Nigel J., Ong, Albert C. M., Bowers, Keith, Adam, Julia M., Adams, David R., Houslay, Miles D., Henderson, David J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613170/
https://www.ncbi.nlm.nih.gov/pubmed/31209056
http://dx.doi.org/10.1073/pnas.1822113116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613170/
https://www.ncbi.nlm.nih.gov/pubmed/31209056
http://dx.doi.org/10.1073/pnas.1822113116

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