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Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis
Replication of eukaryotic genomes relies on the family B DNA polymerases Pol α, Pol δ, and Pol ε. All of these enzymes coordinate an iron–sulfur (FeS) cluster, but the function of this cofactor has remained largely unclear. Here, we show that the FeS cluster in the catalytic subunit of human Pol δ i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Life Science Alliance LLC
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613617/ https://www.ncbi.nlm.nih.gov/pubmed/31278166 http://dx.doi.org/10.26508/lsa.201900321 |