Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

INTRODUCTION: Alzheimer apolipoprotein E (APOE) ε4/ε4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy opposes aggregation, and important autophagy genes are coordinately regulated by transcription factor EB (TFEB) binding to “coordin...

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Detalles Bibliográficos
Autores principales: Parcon, Paul A., Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Jones, Richard A., Liu, Ling, Shmookler Reis, Robert J., Barger, Steven W., Mrak, Robert E., T. Griffin, W. Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613789/
https://www.ncbi.nlm.nih.gov/pubmed/28945989
http://dx.doi.org/10.1016/j.jalz.2017.07.754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613789/
https://www.ncbi.nlm.nih.gov/pubmed/28945989
http://dx.doi.org/10.1016/j.jalz.2017.07.754

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