Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

Mitochondria contain their own genomes, and unlike nuclear genomes, mitochondrial genomes are inherited maternally. With a high mutation rate and little recombination, special selection mechanisms exist in the female germline to prevent the accumulation of deleterious mutations(1–5). The molecular m...

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Detalles Bibliográficos
Autores principales: Lieber, Toby, Jeedigunta, Swathi P., Palozzi, Jonathan M., Lehmann, Ruth, Hurd, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614061/
https://www.ncbi.nlm.nih.gov/pubmed/31092924
http://dx.doi.org/10.1038/s41586-019-1213-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614061/
https://www.ncbi.nlm.nih.gov/pubmed/31092924
http://dx.doi.org/10.1038/s41586-019-1213-4

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