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Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline
Mitochondria contain their own genomes, and unlike nuclear genomes, mitochondrial genomes are inherited maternally. With a high mutation rate and little recombination, special selection mechanisms exist in the female germline to prevent the accumulation of deleterious mutations(1–5). The molecular m...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614061/ https://www.ncbi.nlm.nih.gov/pubmed/31092924 http://dx.doi.org/10.1038/s41586-019-1213-4 |