Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe

Noxa, a Bcl-2 homology 3 (BH3)-only protein of the Bcl-2 family, is responsive to cell stresses and triggers apoptosis by binding the prosurvival Bcl-2-like proteins Mcl1, Bcl(XL), and Bcl2A1. Although the Noxa BH3 domain is necessary to induce apoptosis, the mitochondrial targeting domain (MTD) of...

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Detalles Bibliográficos
Autores principales: Han, Ji-Hye, Park, Junghee, Myung, Seung-Hyun, Lee, Sung Hang, Kim, Hwa-Young, Kim, Kyung Sook, Seo, Young-Woo, Kim, Tae-Hyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614423/
https://www.ncbi.nlm.nih.gov/pubmed/31285435
http://dx.doi.org/10.1038/s41419-019-1753-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614423/
https://www.ncbi.nlm.nih.gov/pubmed/31285435
http://dx.doi.org/10.1038/s41419-019-1753-4

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