Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

The molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely unknown. Particularly, it is unknown what ER luminal factor(s) are involved in ERAD. Herein, we used ProtoArray to identify an ER luminal co-chapero...

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Detalles Bibliográficos
Autores principales: Huang, Yunjie, Arora, Kavisha, Mun, Kyu Shik, Yang, Fanmuyi, Moon, ChangSuk, Yarlagadda, Sunitha, Jegga, Anil, Weaver, Timothy, Naren, Anjaparavanda P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614449/
https://www.ncbi.nlm.nih.gov/pubmed/31285458
http://dx.doi.org/10.1038/s41598-019-46161-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614449/
https://www.ncbi.nlm.nih.gov/pubmed/31285458
http://dx.doi.org/10.1038/s41598-019-46161-4

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