Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition

Accumulation of amino acid (AA) insertions/substitutions are observed in the Gag-protein of HIV-1 variants resistant to HIV-1 protease inhibitors. Here, we found that HIV-1 carrying AA insertions in capsid protein (CA) undergoes aberrant CA degradation. When we generated recombinant HIV-1s (rHIV-1s)...

Descripción completa

Detalles Bibliográficos
Autores principales: Amano, Masayuki, Bulut, Haydar, Tamiya, Sadahiro, Nakamura, Tomofumi, Koh, Yasuhiro, Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614453/
https://www.ncbi.nlm.nih.gov/pubmed/31285456
http://dx.doi.org/10.1038/s41598-019-46082-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614453/
https://www.ncbi.nlm.nih.gov/pubmed/31285456
http://dx.doi.org/10.1038/s41598-019-46082-2

Ejemplares similares