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Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition

Accumulation of amino acid (AA) insertions/substitutions are observed in the Gag-protein of HIV-1 variants resistant to HIV-1 protease inhibitors. Here, we found that HIV-1 carrying AA insertions in capsid protein (CA) undergoes aberrant CA degradation. When we generated recombinant HIV-1s (rHIV-1s)...

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Detalles Bibliográficos
Autores principales:	Amano, Masayuki, Bulut, Haydar, Tamiya, Sadahiro, Nakamura, Tomofumi, Koh, Yasuhiro, Mitsuya, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614453/ https://www.ncbi.nlm.nih.gov/pubmed/31285456 http://dx.doi.org/10.1038/s41598-019-46082-2

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