Copper ion / H(2)O(2) oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action

Copper ion-catalyzed oxidation of yeast SOD1 (ySOD1) was examined to determine early oxidative modifications, including oxidation of a crucial disulfide bond, and the structural and functional repercussions of these events. The study used distinct oxidative conditions: Cu(2+)/H(2)O(2), Cu(2+)/H(2)O(...

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Detalles Bibliográficos
Autores principales: Tiwari, Manish K., Hägglund, Per M., Møller, Ian Max, Davies, Michael J., Bjerrum, Morten J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614508/
https://www.ncbi.nlm.nih.gov/pubmed/31284117
http://dx.doi.org/10.1016/j.redox.2019.101262

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