Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

A large number of natural products have been advocated as anticancer agents. Many of these compounds contain functional groups characterized by chemical reactivity. It is not clear whether distinct mechanisms of action can be attributed to such compounds. We used a chemical library screening approac...

Descripción completa

Detalles Bibliográficos
Autores principales: Selvaraju, Karthik, Mofers, Arjan, Pellegrini, Paola, Salomonsson, Johannes, Ahlner, Alexandra, Morad, Vivian, Hillert, Ellin-Kristina, Espinosa, Belen, Arnér, Elias S. J., Jensen, Lasse, Malmström, Jonas, Turkina, Maria V., D’Arcy, Padraig, Walters, Michael A., Sunnerhagen, Maria, Linder, Stig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614553/
https://www.ncbi.nlm.nih.gov/pubmed/31285509
http://dx.doi.org/10.1038/s41598-019-46168-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614553/
https://www.ncbi.nlm.nih.gov/pubmed/31285509
http://dx.doi.org/10.1038/s41598-019-46168-x

Ejemplares similares