Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase

[Image: see text] Dihydrofolate reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic enzyme that catalyzes the hydride transfer from the cofactor NADPH to dihydrofolate less efficiently than other DHFR enzymes, such as the mesophilic analogue Escherichia coli DHFR (EcDHFR). Using Q...

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Detalles Bibliográficos
Autores principales: Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614790/
https://www.ncbi.nlm.nih.gov/pubmed/31289693
http://dx.doi.org/10.1021/acscatal.9b01250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614790/
https://www.ncbi.nlm.nih.gov/pubmed/31289693
http://dx.doi.org/10.1021/acscatal.9b01250

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