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Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry
[Image: see text] Diphosphatidyltrehalose (diPT) is an immunogenic glycolipid, recently isolated from Salmonella Typhi. Despite rigorous structure elucidation, the sn-position of the acyl chains on the glycerol backbone had not been unequivocally established. A stereoselective synthesis of diPT and...
Autores principales: | Mishra, Vivek K., Buter, Jeffrey, Blevins, Molly S., Witte, Martin D., Van Rhijn, Ildiko, Moody, D. Branch, Brodbelt, Jennifer S., Minnaard, Adriaan J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614791/ https://www.ncbi.nlm.nih.gov/pubmed/31247773 http://dx.doi.org/10.1021/acs.orglett.9b01725 |
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