De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair

Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR. We found that co...

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Detalles Bibliográficos
Autores principales: Ji, Jae-Hoon, Min, Sunwoo, Chae, Sunyoung, Ha, Geun-Hyoung, Kim, Yonghyeon, Park, Yeon-Ji, Lee, Chang-Woo, Cho, Hyeseong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614800/
https://www.ncbi.nlm.nih.gov/pubmed/31045206
http://dx.doi.org/10.1093/nar/gkz309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614800/
https://www.ncbi.nlm.nih.gov/pubmed/31045206
http://dx.doi.org/10.1093/nar/gkz309

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