Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...

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Detalles Bibliográficos
Autores principales: Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://www.ncbi.nlm.nih.gov/pubmed/31127296
http://dx.doi.org/10.1093/nar/gkz354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://www.ncbi.nlm.nih.gov/pubmed/31127296
http://dx.doi.org/10.1093/nar/gkz354

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