TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA

The liver-specific microRNA, miR-122, is an essential host factor for replication of the hepatitis C virus (HCV). miR-122 stabilizes the positive-strand HCV RNA genome and promotes its synthesis by binding two sites (S1 and S2) near its 5′ end in association with Ago2. Ago2 is essential for both hos...

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Detalles Bibliográficos
Autores principales: Li, You, Wang, Li, Rivera-Serrano, Efraín E, Chen, Xian, Lemon, Stanley M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614814/
https://www.ncbi.nlm.nih.gov/pubmed/30997501
http://dx.doi.org/10.1093/nar/gkz278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614814/
https://www.ncbi.nlm.nih.gov/pubmed/30997501
http://dx.doi.org/10.1093/nar/gkz278

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