A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor

Ribonucleoprotein (RNP) complexes and RNA-processing enzymes are attractive targets for antibiotic development owing to their central roles in microbial physiology. For many of these complexes, comprehensive strategies to identify inhibitors are either lacking or suffer from substantial technical li...

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Detalles Bibliográficos
Autores principales: Madrigal-Carrillo, Ezequiel-Alejandro, Díaz-Tufinio, Carlos-Alejandro, Santamaría-Suárez, Hugo-Aníbal, Arciniega, Marcelino, Torres-Larios, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614837/
https://www.ncbi.nlm.nih.gov/pubmed/30997498
http://dx.doi.org/10.1093/nar/gkz285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614837/
https://www.ncbi.nlm.nih.gov/pubmed/30997498
http://dx.doi.org/10.1093/nar/gkz285

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