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Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics
The viral RNA (vRNA) genome of influenza viruses is replicated by the RNA-dependent RNA polymerase (RNAP) via a complementary RNA (cRNA) intermediate. The vRNA promoter can adopt multiple conformations when bound by the RNAP. However, the dynamics, determinants, and biological role of these conforma...
Autores principales: | Robb, Nicole C, te Velthuis, Aartjan J W, Fodor, Ervin, Kapanidis, Achillefs N |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614853/ https://www.ncbi.nlm.nih.gov/pubmed/31032520 http://dx.doi.org/10.1093/nar/gkz313 |
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