Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex

Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is removed from the genome much faster than the cyclobutane pyrimidine dimer (CPD), owing to the more efficient recognition of 6-4PP...

Descripción completa

Detalles Bibliográficos
Autores principales: Paul, Debamita, Mu, Hong, Zhao, Hong, Ouerfelli, Ouathek, Jeffrey, Philip D, Broyde, Suse, Min, Jung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614856/
https://www.ncbi.nlm.nih.gov/pubmed/31106376
http://dx.doi.org/10.1093/nar/gkz359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614856/
https://www.ncbi.nlm.nih.gov/pubmed/31106376
http://dx.doi.org/10.1093/nar/gkz359

Ejemplares similares