Cargando…
Metabolic requirements of human pro-inflammatory B cells in aging and obesity
The subset of pro-inflammatory B cells, called late memory, tissue-like or double negative (DN), accumulates in the blood of elderly individuals. Here we show that DN B cells do not proliferate and do not make antibodies to influenza antigens, but they secrete antibodies with autoimmune reactivity,...
Autores principales: | Frasca, Daniela, Diaz, Alain, Romero, Maria, Thaller, Seth, Blomberg, Bonnie B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615614/ https://www.ncbi.nlm.nih.gov/pubmed/31287846 http://dx.doi.org/10.1371/journal.pone.0219545 |
Ejemplares similares
-
B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
por: Frasca, Daniela, et al.
Publicado: (2021) -
Phenotypic and functional features of B cells from two different human subcutaneous adipose depots
por: Frasca, Daniela, et al.
Publicado: (2023) -
Secretion of autoimmune antibodies in the human subcutaneous adipose tissue
por: Frasca, Daniela, et al.
Publicado: (2018) -
Obesity Accelerates Age-Associated Defects in Human B Cells Through a Metabolic Reprogramming Induced by the Fatty Acid Palmitate
por: Frasca, Daniela, et al.
Publicado: (2022) -
Obesity accelerates age defects in B cells, and weight loss improves B cell function
por: Frasca, Daniela, et al.
Publicado: (2023)