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Exact and efficient hybrid Monte Carlo algorithm for accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts

Single cells exhibit a significant amount of variability in transcript levels, which arises from slow, stochastic transitions between gene expression states. Elucidating the nature of these states and understanding how transition rates are affected by different regulatory mechanisms require state-of...

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Detalles Bibliográficos
Autores principales: Lin, Yen Ting, Buchler, Nicolas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615996/
https://www.ncbi.nlm.nih.gov/pubmed/31301707
http://dx.doi.org/10.1063/1.5110503