Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling

Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial inhibitory effect of dapagliflozin, a SGLT2 inhibitor, on TIF, but the underlying mechanisms remain largely unknown. This study aimed...

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Detalles Bibliográficos
Autores principales: Huang, Fengjuan, Zhao, Yanyan, Wang, Qingzhu, Hillebrands, Jan-Luuk, van den Born, Jacob, Ji, Linlin, An, Tingting, Qin, Guijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616082/
https://www.ncbi.nlm.nih.gov/pubmed/31333586
http://dx.doi.org/10.3389/fendo.2019.00441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616082/
https://www.ncbi.nlm.nih.gov/pubmed/31333586
http://dx.doi.org/10.3389/fendo.2019.00441

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